What are "peripheral blood stem cells" ?
PBSCs are hematopoietic stem cells (HSCs) that are circulating in the blood. HSCs circulate at low levels in the blood all the time but can increase in number dramatically when a person is treated with certain cytokines (substances that stimulate the bone marrow) such as G-CSF (a natural factor also produced by your body) or when hematopoietic (bone marrow) recovery occurs following chemotherapy. PBSC transplants tend to engraft faster than bone marrow transplants presumably because
they have greater a proportion of mature progenitors. When patients hear and talk about “stem cell transplants” they are typically referring to peripheral blood stem cell transplants. Stem Cells are normally found in the bone marrow but it is possible to move them out of the marrow into the bloodstream so that they can be collected easily.
Adult Peripheral Blood Stem Cell Collection (PBSC) Service Apart from Umbilical Cord Blood Stem Cell Service THAI StemLife offers an adult service as well, that is Peripheral Blood Stem Cell Collection. Why? A biological insurance for us that are born without having had the opportunity to keep cord blood for the future! PBSC can be used to treat heart diseases, diabetic ulcers, autoimmune diseases and in the future maybe even stroke, Parkinson’s, and Alzheimer’s. Keeping your PBSC at a young age ensures that their efficiency and availability is at its best when needed at an older and/or diseased age.
How do you move stem cells from bone marrow to peripheral bloodstream?
This process is known as ‘mobilization’ of stem cells. Stem cells are mobilized with a once daily injection of G-CSF for 4-5 days before the stem cells are collected.
How are the stem cells collected? THAI StemLife uses the latest model of an apheresis machine that is also used in the routine collection of peripheral blood stem cells when a donation is necessary, found in all modern University Hospitals that are able to perform bone marrow transplants. A blood collection needle is placed in an arm vein, blood travels to the machine and the stem cells are separated from it. The stem cells are collected in a collection bag while the rest of the blood returns through a second needle to the opposite arm. The entire procedure requires approximately 2-4 hours, the length of a good movie.
Do you want to know
what your OWN Stem Cells look like?
Adult Stem Cell Collection from Peripheral Blood:
Most of us have missed the opportunity to collect cord blood and tissues at birth! But do not despair, even for us there is still hope to collect our own stem cells for future treatments before a disease strikes.
THAI StemLife is the leader in Thailand (1) in peripheral blood stem cell collection using a THAI and US FDA approved protocol and machine called Leukapheresis. This process is the usual process performed all over the world when people need to donate stem cells to their own siblings and relatives or other tissue compatible recipients in need of a bone marrow transplantation.
In our process you simply donate your own cells in advance to your future self! After stimulating your bone marrow for 5 days with a medication called G-CSF, that is the same substance your body produces and uses to stimulate production of stem cells, you will be painlessly connected to the leukapheresis machine for 4 hours and billions of your own stem cells will be collected. It is only a small fraction of what your bone marrow contains, so do not worry, your body has amazing reserves. Those stem cells will be cryogenically stored in bags and vials for future needs. There will be enough for a lifesaving bone marrow transplant should the need arise for treatments of blood or solid cancers, lymphomas, immune system disorders and multiple myeloma (2). Newer indications also include autoimmune diseases like MS, SLE, RA and many more. Encouraging results from recent studies support the use in traumatic brain injuries both in children and adults but the window of treatment is short and thus storage is imperative.
Our experience in collecting and releasing samples is unparalleled in Thailand and SE Asia, and absolutely none of our competitors have even remotely accomplished anything similar to our over 97 adult stem cells releases.
We, at THAI StemLife we have released Thailand’s and Asia’s FIRST peripheral blood stem cell sample for Multiple Sclerosis already in 2009.
Importantly THAI StemLife is the first stem cell bank in Thailand to release patients' own stem cells for treatment Diabetic Ulcers of which has earned us the NIA Top Innovation award in 2006 (3).
Moreover, improvement in early Osteoarthritis to avoid total knee replacement was proven by our 3 internationally published and appraised studies at the Police General Hospital that are continuously being cited (to date more than 72 times) by later researchers! More indications exist, and more are under research for future applications.
If you do not have time to spend with our leukapheresis machine, there is an alternative for you called AUTO MiNi PBSC. Click to learn more.
Do not let this opportunity pass you by. There in so sadder moment in life than knowing there is a cure for your life-threatening condition but you cannot access it.
W. Fongsarun, M. Paisan, K. Papadopoulos. Differential effect of prognostic factors in health and disease in Peripheral Blood Stem Cell (PBSC) mobilization and collection: A single-center/doctor experience in autologous harvest. THAI StemLife, Bangkok, Thailand. CYTOTHERAPY 19 (5), S53-S54. (https://www.celltherapyjournal.org/article/S1465-3249(17)30175-5/fulltext)
Duarte RF, Labopin M, Bader P, et al. Indications for haematopoietic stem cell transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe, 2019. Bone Marrow Transplant. 2019;54(10):1525-1552. doi:10.1038/s41409-019-0516-2
Papadopoulos KI, Jatuvorapat J, Tanisaro K, Danpongchareon K, Buapradit P, Chantarojanasiri T. IMPLANTATION OF AUTOLOGOUS GRANULOCUTE COLONY STIMULATING FACTOR (G-CSF) MOBILIZED PERIPHERAL BLOOD STEM CELLS (PBSC) IN TREATING PERIPHERAL ARTERIAL DISEASE (PAD)-EFFECT OF DOSE AND METHOD OF ADMINISTRATION. Presented at: 14th Annual Meeting of the Royal Thai Endocrine Society, Bangkok, Thailand. 2nd Annual STEM CELLS & REGENERATIVE MEDICINE EUROPE 2009 Conference. 4th World Congress on Regenerative Medicine, March 12-14, 2009, Bangkok, Thailand. Regenerative Medicine by the New York Academy of Sciences, the Chinese Academy of Medical Sciences, and the Chinese Ministry of Health, May 15-16, 2009, Beijing, China. Abstract and oral presentation at the 2nd International Congress on Responsible Stem Cell Research (RSCR), Monaco, 2009 and at the 8th Asia-Pacific Burn Congress and the 3rd Congress of the Asian Wound Healing Association, BITEC, Bangkok, Thailand, 2011.