Human Placental

Extract (HUPE)

At THAI StemLife, you can also create a personalized sterile extract from your placenta, frozen in vials with characterized growth factor content for future uses. Placenta has been a traditional oriental folk remedy (1).

We know today that HUPE is a rich resource of various bioactive substances such as RNA, DNA, peptides, amino-acids, proteins, lipids, and enzymes (2).

It demonstrates potent antioxidant properties associated with the protein components, especially alpha-fetoprotein (2).

It contains transforming growth factor-beta (TGF-β) and vascular endothelial growth factor (VEGF) involved in blood vessel mechanics, and a large number of growth factors (GM/G-CSF, HGF, EGF, PDGF, IGF) that participate in many regenerative processes It promotes increased synthesis of regeneration-related protein factors such as GAP-43 and Cdc (3).

HUPE is rich in cytokines (IL-1, 2, 4) that promote diverse immune system effects (3).

Placental biomaterials are easily accessible and personalized additions to regenerative medicine applications due to their low immunogenicity, positive wound/skin healing characteristics and minimal tissue inflammation (3).

Reference:

  1. KM Park, DP Cho, TH Cho. Placenta Therapy: Its Biological Role of Anti-Inflammation and Regeneration. DOI: 10.5772/intechopen.79718

  2. Wang Y, Zhao S. Vascular Biology of the Placenta. From: Chapter 10, Placental Tissue and Cord Blood Stem Cells. San Rafael (CA): Morgan & Claypool Life Sciences; 2010.

  3. Moore MC, Van De Walle A, Chang J, Juran C, McFetridge PS. Human Perinatal-Derived Biomaterials. Adv Healthc Mater. 2017 Sep;6(18):10.1002/adhm.201700345. doi: 10.1002/adhm.201700345. Epub 2017 Aug 7. PMID: 28783879; PMCID: PMC5733692.

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