The Most Advanced IEMs Screening Technology
If your child fails to thrive, appears irritable, feeds poorly, ask your pediatrician
to test for IEMs.
Our urine-based META-Child test, is uses Most Advanced Inborn Errors of Metabolism (IEMs) Screening Technology, to screen for over 150 metabolic conditions that can impact on your child’s development. The test will be analyzed at our NSQAP & ERNDIM (*) accredited laboratories in Japan and early detection of those conditions can be life altering for a child.
Collectively, inborn Errors of Metabolism (IEMs: otherwise known as metabolic disorders) refers to a group of rare genetic disorders in which the body cannot metabolize food components normally.
Usually caused by defects in the enzymes that break down food components.
Collectively, Inborn error of metabolism (IEM) may affect 1 out of 800 births (1) to 1 in 3165 births (2).
Phenylketonuria (PKU) is a classic example and if diagnosed early, the child will thrive normally! Early diagnosis and simple treatment could avoid early mortality and prevent or reduce mental retardation. Our laboratories have been instrumental in assisting clinicians to confirm suspicion for high-risk cases (particularly in organic aciduria cases). To date, we have screened more than 380,000 individuals, and identified 3500 patients with 75 different IEMs. Our testing methodology is simple and non-invasive, and can be performed easily by parents, or hospital personnel using MetaChild’s patented collection device (JP3475834B2). The collection bag allows for remote areas collection as well as transportation for prolonged periods (3 to 4 days prior to sample processing). The Gas Chromatography-Mass Spectrometry (GC-MS) used by MetaChild is NSQAP & ERNDIM (*) accredited.
1. Amino acid metabolic disorders
2. Carbohydrates metabolic disorders
3. Organic acid metabolic disorders
4. Fatty acid metabolic disorders
5. Lactic acid, hyperpyruvic acid metabolic disorders
The List of IEMs include:
6. Nucleic acid metabolic disorders
7. Peroxisomal metabolic disorders
8. Purine & pyrimidine metabolic disorders
9. Urea Cycle metabolic disorders
10. Other target diseases
What is MetaChild?
A newborn screening test for the detection of many severe & fatal metabolic disorders (inborn errors of metabolism, IEMs)
Screening on urine samples, non-invasive
The reports tell you the levels of
Baby with IEM doesn't appear
abnormal at the early beginning
However, baby lacks enzyme to break down normal formula milk properly
Eventually baby become sick and start to have symptoms like vomiting, seizures
Why you need MetaChild?
Abnormal eye findings (cataract, retinopathy, etc.)
High risk factors:
Advanced maternal age
Reproductive failures in mother
Stillbirth / neonate death / perinatal death in mother
Previsions prematurity / IUGR/LBW / placental abnormalities
Mental retardation in family
Congenital anomalies & physical deformities
Previous child with chromosomal anomalies
Epileptic mother on antiepileptic drugs
Drugs intake / irradiation during pregnancy
Exposure to toxic (carcinogenic / teratogenic) agents
How does MetaChild work?
FAQ of MetaChild
Q1: When is the best time to have MetaChild?
A1: You may schedule MetaChild during pregnancy and have the test within 3-5 days after the birth of your baby.
Q2: My baby did not have MetaChild at the best time, is it possible to have the test later on?
A2: Yes. Since the onset of most of inborn errors of metabolism is from birth to 12 years old, your baby may have MetaChild later on.
Q3: When will I get MetaChild results?
A3: The results will be ready 3-5 days after the laboratory received urine samples.
Q4: Where should I go if I would like to schedule MetaChild?
A4: You may check with THAI StemLife-CONTACT US.
Q5: What if my babys MetaChild result is abnormal?
A5: If a test result comes back abnormal, try not to panic. This does not necessarily mean that your baby has a disorder. A screening test is not the same as diagnostic test. If this happens, the laboratory will contact your paediatrician. Diagnostic testing will be necessary to confirm the diagnosis.
Q6: Why is it important to have MetaChild?
A6: Early detection allows early treatment. Since many of the harmful effects of metabolic disorders can be reduced, either by diet or medication, treatment is best if started early.
(*) Newborn Screening Quality Assurance Program NSQAP & European Research Network for evaluation and improvement of screening, Diagnosis and Treatment of Inborn errors of Metabolism ERNDIM